Atletico Madrid currently sit at the top of La Liga, but only thanks to goal difference over Real Madrid.
Real Sociedad are also hanging around the top of the table, just three points behind Atletico and Real.
As a result, this game could have huge title implications, with Simeone looking to secure three points and open up a six-point gap between Atletico Madrid and Real Sociedad.
Superstar Joao Felix is a major doubt, while Jose Gimenez could also be ruled out as he attempts to prove his fitness.
Diego Costa is back in contention after making his return in the game against Elche at the weekend.
Sociedad will definitely be without the services of Adnan Januzaj, David Silva and Mikel Oyarzabal, and have a number of other injury concerns to deal with.